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Immunotherapy with Ipilimumab can be applied to advance melanoma with brain metastases
An immunotherapy with Ipilimumab for the patients with advance melanoma developed brain metastases showed in line with those without brain metastases. This indication found after the researchers from UK studied 72 patients with such indications received 4 doses of 10 mg/kg (3 times higher with current label) of intravenous ipilimumab per 3 weeks for outcomes assessment at 12 weeks. At study entry, the history of 72 patients, 51 patients were had neurologic asymptomatic without receiving corticosteroid and 21 patients were had symptomatic with stable doses of corticosteroids. At the end of assessment, the disease control in the asymptomatic patients showed in 9 patients (18%) and 24% for the brain alone, whereas in the symptomatic patients showed in 1 patients (5%) and 10% for the brain alone. They also added that the survival rate for … Read entire article »
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Drug adverse effects from Anticoagulants and Diabetes meds causes almost hundred thousands of hospitalization
Several studies have shown adverse drug events of emergency hospitalization from several types of drug classified as insulins, warfarin, oral antiplatelet, and oral hypoglycemic agents both alone or in combination. However, most of … Read more »
Factors affecting the healing of an illness
Factors affecting the healing of diseases: 1. The accuracy of diagnosis. This is the main gate towards the right treatment. The accuracy of diagnosis influenced some of following: - Knowledge of one’s illness. The more familiar with … Read more »
Higher than average for death risk rate caused heart failure among people who live in ‘stroke belt’ region in US
The national average of death related to heart failure in the U.S. is about 18 per 100,000 people. However, for those who live in ‘stroke belt’ region such as Alabama, Arkansas, Georgia, Louisiana, … Read more »
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Vaginal prolapse surgery treatment with laparoscopic sacral colpopexy (LSC) more effective than total vaginal mesh (TVM)
Vaginal vault prolapse or female genital prolapse is bulging of the top of the vagina into the lower vagina or outside the opening of the vagina. The condition usually occurs when the pelvic … Read more »
Pupillary light response after used neuromuscular blockade agents of succinylcholine or rocuronium
Recently, the researchers investigated whether Succinylcholine or Rocuronium (short-acting neuromuscular blocking agents) affected pupillary response or dilation of the pupil to the light, because theoretically this agents could impairs pupillary response. The researchers … Read more »
Causes and cure for male pattern baldness
As previously announced the results of research done by researchers from King's College London and GlaxoSmithKline, that even they have identified two genetic variants in Caucasians as well as chromosome 20 to … Read more »
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Reduce Opioids and NSAIDs use in renal colic treatment with Papaverine
Since use of Opioids and NSAIDs at higher risk of several complications both in long- and short-term administration, particularly to the patients with the pain of renal colic, the researchers found other alternative treatment but effectively enough in relieving the pain. The researchers from Iran said that supplementing diclofenac suppositories with intravenous papaverine showed effectively relieve the pain of renal colic. This outcomes obtained after they conducted randomized trial of 550 patients suspected with renal colic received diclofenac (100 mg) alone or diclofenac sodium suppository with intravenous of either 1.5 mg/kg papaverine hydrochloride or saline. According to the findings published in BJU International on February 20, 2012, 91% of diclofenac-papaverine group reduced analgesia (25 mg pethidine IM) use … Read entire article »
Contagious skin disease of Scabies can be effectively treated with Permethrin and Ivermectin
Those with Scabies caused by the mite Sarcoptes scabiei may try treated with Permethrin or Ivermection. This is because both those medications showed effectively in treating this highly contagious skin disease. Recent study conducted by researchers from Iran found that both those medications highly effective in curing scabies patients after several weeks with 1-week interval. According to their findings published in the Journal of Dermatology on March 5, 2012 (ref), the rate in curing Scabies were 85.9% with single dose of oral Ivermection after 2 weeks of treatment and increased to 100% at 4 weeks post-treatment, while curing scabies with permethrin cream (2 applications with 1-week interval) offering 92.5% in curing rate at 2 weeks post-treatment. This findings … Read entire article »
Guidelines for colorectal cancer screening by ACP
In general, the American College of Physicians (ACP) encourages adults (aged 50 years and older) for screening related to Colorectal cancer (CRC) risk because of some evidences in reducing mortality risk related to the disease, despite other studies also found no benefits and even harmful. However, based on 4 guidelines developed by other professional organizations such as the American Cancer Society, US Multi-Society Task Force on Colorectal Cancer, American College of Radiology, and Institute for Clinical Systems Improvement, the ACP recommends the following: - Clinician should perform individual CRC risk evaluation in all adults. Risk factors for CRC incidence and mortality include older age, black race, personal history of polyps, inflammatory bowel disease, CRC, and family history … Read entire article »
Vitamin D reduce stress fracture risk and not to Calcium intake
Calcium intake or dairy rich in Calcium currently suggested helps bone health and beneficial for those who actively exercise, including exercise that need bone stresses to withstand the forces such as high-impact sports. However, those suggestion may not completely right as current findings found that those link was failed in reducing fractures risk in sport injury due to exceed capacity of stresses on the bone. In fact, Calcium increase that risk. Surprisingly, the risk of stress fracture was reduced by high intake of vitamin D. In other words, Vitamin D is beneficial for bone health to those who have active exercise than Calcium. This findings obtained after the researchers analyzed data of the Growing Up Today Study on 6712 … Read entire article »
More evidences, BPA exposure linked to heart disease
Although the use of Bisphenol A (BPA) on various products become commonplace in people’s live and used almost the entire population in the worlds, but the studies that have absolute conclusion and recommendation regarding to BPA use was too little, so it is not been able to give a definitive decision. Several studies have investigated the adverse effects of BPA, especially those related to coronary heart disease (CHD). However, the final results of the study still needs further study to confirm the relationship. Recent study adds more evidences regarding to negative effect of BPA exposure, especially in food packaging to heart disease risk. According to the findings published in Circulation on February 21, 2012, BPA exposure indicated through … Read entire article »
Proton pump inhibitors (PPIs) may not causes small intestinal bacterial overgrowth
As previous studies suggested a relationship between small intestinal bacterial overgrowth (SIBO) and use of proton pump inhibitor (PPI) drugs, recent studies said that those link not completely right. While previous studies showed complicating results where is European studies mostly indicated positive effect between PPIs and SIBO, but US studies mostly indicated negative effect; which is suggesting dietary factor may influence the outcomes, lack of standard test to diagnose SIBO, and various duration and dose of PPIs use, current studies used patients with chronic acid suppression therapy that would be expected to increase the potential for an abnormal glucose hydrogen breat testing (GBHT), a testing of breath sample for hydrogen (H2) and methane (CH4) to … Read entire article »
Iodinate Contrast Media (ICM) increased risk hyperthyroidism
The use of Iodinated Contrast Media (ICM) in the radiographic to see the structure and condition of blood vessels and organs helped physicians in detecting possible pathologic of cancer, malignancy, and other abnormal conditions. However, some side effects of this therapy also needs to watch out for early prevention. While may causes life-threatening in patients with certain medical conditions, recent study also indicated if ICM may also lead to increased production of thyroid hormone due to hyperthyroidism development. Side effects of ICM to hyperthyroidism risk was discovered after researchers from Harvard Medical School in Boston performed a nested case-control study of adult patients who were euthyroid at baseline and who were exposed to ICM from the Partners … Read entire article »
Early detection of stroke and dementia risks from parental history of early stroke
The researchers suggest the possible need for screening in middle-aged children of parents who have a history of early stroke (before the age of 65 years) due to the possibility of changes in brain structure and risk of cognitive dysfunction in these children for later life. This is because based on the results of community-based study of the Framingham Heart Study (FHS) offspring which is involved 1297 participants were relatively young found that those who have a history of parental stroke associated with higher white matter hyperintensity volume at baseline, baseline performance of visuospatial memory, more likely in the highest quintile of increases in the volume of white matter hyperintesities, and worsening executive function, compared to … Read entire article »
Symbiotic improve bowel movement in patients with chronic constipation
Symbiotics or Eubiotics is a supplementation containing good bacteria (probiotic) and its food (prebiotic). The advantage of this type of supplement than probiotics or prebiotics alone is increasing survival of probiotics when entering digestive system to the intestine and finally improve the balance of intestinal microflora. There are various foods for probiotics. However, recent study from researchers at the Hospital Santa Catarina, Sao Paulo, Brazil, said that good bacteria of Lactobacillus paracase, L. rhamnosus, L. acidophilus, and Bifidobacterium lactis with their food of Fructo-Oligosaccharides showed significantly improved bowel movement of their patients with chronic constipation compared to placebo groups. From a study period (4 weeks), every 2 weeks of observation, the probiotics + food groups showed higher … Read entire article »
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